OSAPlex MK-7

Bone health is essential to overall health and vitality, and bones are dependent on a constant supply of micronutrients for maintenance and repair. It is widely known that minerals such as calcium and phosphorus are vital to bone maintenance; however, bone strength is ultimately dependent upon minerals binding to flexible core posts inside the bone. These flexible posts are made from collagen, a protein whose production is stimulated by the mineral silicon. Collagen is essential to maintaining the number of bone-calcium binding sites available, and therefore essential, to maintaining bone integrity, flexibility, and strength as we age. OSAPlex MK-7 provides nutrients that work together to support bone production, strength, and maintenance. This multifaceted approach is an important factor in enhancing absorption of bone- building nutrients and preventing select vitamin and mineral depletions.*Calcium Revolution Health & Wellness Clinic’s microcrystalline hydroxyapatite concentrate (MCHC) from Bone Support contains a premium, proprietary, standardized bone extract from New Zealand bovine and provides a crystalline calcium and phosphorus matrix in the ideal physiological ratio of 2:1. Ossopan, in Bone Revolution, delivers bioactive growth factors and type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements. Scientific studies on Ossopan, over a span of four decades, suggest that Ossopan supplementation fundamentally supports bone health.*[1-4]Vitamin D OSAPlex MK-7 contains cholecalciferol (vitamin D3), the same form that is endogenously synthesized from cholesterol in the presence of UV light from the sun. Vitamin D is needed to maintain blood levels of calcium and phosphate for normal bone metabolism. A randomized, population-based, three-year trial on women aged 65 to 71 indicated that daily supplementation with vitamin D and calcium had a positive and statistically significant impact on total body bone integrity.*[5]

Menaquinone-7 (MK-7) Bone Revolution contains menaquinone-7, a bioactive form of vitamin K2 (the menaquinone form of vitamin K). Vitamin K plays an active role in bone metabolism and is required for calcium utilization because it activates osteocalcin, the protein needed to bind calcium to the mineral matrix in bone. Vitamin K exerts additional protective effects as it supports bone integrity by moderating the synthesis of prostaglandin E2 and interleukin-6 by osteoclasts.[6,7]. As the natural, long-chain form of vitamin K, MK-7 was found to reach higher and more prolonged serum levels when compared to a synthetic form of vitamin K and also to have a more profound effect on osteocalcin.*[8]

RejuvN8 Silicon has been found to directly stimulate collagen type I synthesis in human bone-forming cells, enhance osteoblast differentiation, and support bone flexibility resulting in greater resistance to physical stress.[9,10] A patented, stabilized silicon in the form of ch-OSA® (choline-stabilized orthosilicic acid) in Bone Revolution provides stimulation and support for collagen production. As a collagen-generating complex, ch-OSA links single chains of amino acids together to form collagen strands, which then create the core-post “binding sites” for calcium and other bone minerals.*[11,12]

A 12-month, randomized, double-blind, placebo-controlled trial suggested that individuals given ch-OSA in addition to calcium and vitamin D3—versus calcium and vitamin D3 alone—experienced a significant improvement in P1NP (serum procollagen type 1 N-terminal propeptide), the most sensitive bone formation marker. Results also suggested an overall positive trend for other bone formation markers and a significant improvement in femoral neck T-score with a 6 mg dose of ch-OSA. Additionally, the ch-OSA group showed no adverse effects.*[13]

OSAPlex MK-7 is a comprehensive, multinutrient formula that provides the fundamental components needed for bone and skeletal health. Instead of adopting a single-nutrient, unbalanced approach to supplementation, utilize OSAPlex MK-7 to help build and maintain healthy bone over time.*

Directions

Consume the contents of one packet with a meal, one to two times daily, or as directed by your healthcare practitioner.

Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Consider total vitamin K intake (food + supplements) if you are taking blood-thinning medication. Present studies show that 45 mcg of MK-7 from Vitamin k2 daily is not likely to interfere with blood-thinning medicines.

References

1. Pelayo I, Haya J, De la Cruz JJ, et al. Raloxifene plus ossein-hydroxyapatite compound versus raloxifene plus calcium carbonate to control bone loss in postmenopausal women: a randomized trial. Menopause. 2008 Nov-Dec;15(6):1132-8. [PMID: 18791486]
2. Castelo-Branco C, Pons F, Vicente JJ, et al. Preventing postmenopausal bone loss with ossein-hydroxyapatite compounds. Results of a two-year, prospective trial. J Reprod Med. 1999 Jul;44(7):601-5. [PMID: 10442322]
3. Albertazzi P, Steel SA, Howarth EM, et al. Comparison of the effects of two different types of calcium supplementation on markers of bone metabolism in a postmenopausal osteopenic population with low calcium intake: a double-blind placebo-controlled trial. Climacteric. 2004 Mar;7(1):33-40. [PMID: 15259281]
4. Castelo-Branco C, Martinez de Osaba MJ, et al. Ossein-hydroxyapatite compounds for preventing postmenopausal bone loss. Coadjuvant use with hormone replacement therapy. J Reprod Med. 1999 Mar;44(3):241-6. [PMID: 10202741]
5. Kärkkäinen M, Tuppurainen M, Salovaara K, et al. Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65-71 years: a 3-year randomized population- based trial (OSTPRE-FPS). Osteoporos Int. 2010 Dec;21(12):2047-55. [PMID: 20204604]
6. Weber P. Management of osteoporosis: is there a role for vitamin K? Int J Vitam Nutr Res. 1997;67(5):350-6. [PMID: 9350477]
7. Shearer MJ. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc. 1997 Nov;56(3):915-37. [PMID: 9483660]
8. Schurgers LJ, Teunissen KJ, Hamulyák K, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83. [PMID: 17158229]
9. Reffitt DM, Ogston N, Jugdaohsingh R, et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone. 2003 Feb;32(2):127-35. [PMID: 12633784]
10. Jugdaohsingh R, Tucker KL, Qiao N, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res. 2004 Feb;19(2):297-307. [PMID: 14969400]
11. Calomme MR, Vanden Berghe DA. Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage. Biol Trace Elem Res. 1997 Feb;56(2):153-165. [PMID: 9164661]
12. Calomme MR, Geusens P, Demeester N, et al. Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. Calcif Tissue Int. 2006, Apr;78(4): 227-232. [PMID: 16604283]
13. Spector TD, Calomme MR, Anderson SH, et al. Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskelet Disord. 2008 Jun 11;9:85. [PMID: 18547426]